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Milano bicocca in monza, italy, and colleagues. The finding is an "indication of how profoundly imatinib has changed the clinical course" of the disease, gambacorti-passerini and colleagues argued online in the journal of the national cancer institute. Indeed, the advent of imatinib and similar agents "create a platform from which we can entertain the possibility of curing" the disease without a stem cell transplant, argued b. Douglas smith, md, of the sidney kimmel comprehensive cancer center in baltimore. "it is now time for clinical and laboratory investigators to build on this platform and work to turn good and great responses into cures," smith argued in an accompanying editorial. Imatinib, a tyrosine kinase inhibitor that targets the so-called philadelphia chromosome characteristic of chronic myeloid leukemia, was the first to yield complete and lasting responses and is now widely used as first-line treatment, the researchers noted. But most information on the long-term effects of the drug has come from industry-sponsored trials at selected centers, they added. To help fill the gap, the independent imatinib long-term (side) effects study -- conducted in 27 centers on five continents -- enrolled 832 patients who started treatment with the drug before 2005 and were in complete cytogenetic remission after two years of therapy, gambacorti-passerini and colleagues reported. The analysis looked at data on toxic events (related and unrelated to the leukemia), loss of complete cytogenetic remission, and cumulative incidence of death over a total of 3,247 person-years of follow-up. Over the follow-up period -- a median of 3. 8 years -- the researchers found 20 deaths in the study population, for a mortality rate o. buy viagra Preparada
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